The Brain and Alcohol | Genetic Predisposition

by Kerri MacFarlane | Oct 15, 2022 | Alcohol Free, Blog, Helpful Tips, Resources, Science and alcohol

Let’s talk about science and alcohol.  It’s a pretty interesting and popular subject when the topic of recovery and sobriety gets brought up.  

But let’s keep in mind that it’s not enough to rely on science and information to ditch the booze. Yes, it’s interesting and knowledge is power, but please don’t solely rely on knowledge, science and information alone to quit drinking. If we could read or listen ourselves out of a drinking problem, well, the problem would be solved. ??

Paul loves the science part of addiction and recently did a podcast intro on just that. (RE Episode 396)  

Paul got most of his info from a fantastic podcast episode from the Huberman Lab Podcast, What Alcohol Does to Your Brain, Body & Health| Episode 86.   I highly recommend you check it out and listen when you get a chance…Dr. Huberman goes into great detail in this 2 hour episode and even those without a drinking problem will find it interesting and beneficial.  

Andrew Huberman, Ph.D., is a neuroscientist and tenured Professor in the Department of Neurobiology at the Stanford University School of Medicine.

Alcohol and the brain. ??

Alcohol has many biochemical and neurochemical effects on the brain. There are dramatic changes in the neurons that control the release of serotonin when we consume alcohol. Serotonin is the feel good chemical and 80% of it is created in the gut. When we mix alcohol and serotonin it gets converted into acetaldehyde. Acetaldehyde damages your DNA and prevents your body from repairing the damage.  A toxic buildup of acetaldehyde can increase your cancer risk.

This acetaldehyde acts as a toxin at the very synapses and the connections between the serotonergic neurons and lots of other neurons. In other words, when we ingest alcohol, the toxic effects of alcohol disrupt those mood circuitries.

It does this first ☝?by making them hyper active. 

This is why people become happy or more talkative after a couple of sips of alcohol.  But when the alcohol wears off the serotonin levels and the activity of brain circuits really start to drop and this is why most people head to the bar for a second round. Now typically what happens when people ingest their 3rd, 4th or 5th drink, there is an absolute zero chance of them recovering that energized mood they experienced on the first drink. Most people, when they drink more and more, begin to feel suppressed ?. The front part of the brain, the frontal cortex, is starting to shut down.  The motor areas of the brain that control motion and basic functions begin to slow. 

This is the slurred speech, the swaying back and forth, the classic drunk shuffle. People begin to lean on things, uncomfortable benches seem like a good place to spend the night. There is a great depression, not of the psychiatry sort, but a depression of alertness and arousal, and eventually people begin to pass out. ?

Here’s one big way that alcohol changes your brain chemistry.  

Alcohol changes the relationship between the hypothalamus, the pituitary gland and the adrenals.  The hypothalamus, which is about the size of a gumball and sits above the roof of the mouth, provides a specific set of signals for the pituitary gland…which then releases hormones into the bloodstream that go and talk to you adrenals which sit right above your kidneys in your lower back. The adrenals release a chemical called epinephrine and cortisol which is involved in the longer term stress response. 

The hypothalamus, the pituitary gland and the adrenals maintain the physiological balance of what you perceive as stressful.   People who consistently drink are more stressed out at baseline then sober peeps. They have more cortisol released from their adrenal glands even when they are not drinking. And a consequence of this is they feel more stressed and feel more anxiety when they are not drinking. Most medical professionals will agree that stress is the number one contributor to disease.

Let’s talk about blackouts for a second. Blacking out is not passing out. When we overload the brain with alcohol, it’s almost too much to process and the activity of neurons in the hippocampus, which is involved with memory formation, are strained and then they completely shut off. As in you no longer form memories. You are still awake and can still be functioning, some high functioning, but the memory forming part of your brain, the hippocampus, clocks out.

Now…to genetic predisposition…

Side note, Paul doesn’t believe in genetic predisposition to alcoholism. He used to, but now he doesn’t.  

Addiction guru Dr. Gabor Mate’s teaching rebukes the genetic myth. Dr. Mate feels all addictions are trauma responses. What helped Dr. Mate reach this conclusion was his studying of twins who have the same genetic makeup.  He also studies twins with the same genetic makeup who are separated at birth. His conclusion is that all addictions are environmental responses, or coping behaviors that allow people to survive in unhealthy environments.

Dr. Bruce Lipton, who is coined the father of Epigenetics in the 90’s, would also agree with this. Epigenetics says it’s the environment that controls the expression of genes and gene mutations. In addition, it’s the environment that cues anxiety, depression, addiction, auto immune responses, cancers, inflammations, and not genetics. The classic Rat Park experiment by Bruce Alexander in the 70’s also shows addictions are environmental. 

Paul says, “I am on board with this approach and even in the past 8 years doing Recovery Elevator, I’ve seen the pendulum slightly shift in this direction.”   What we’re seeing now, is our biological makeup is much more adaptive and reflexive to environments than previously thought. Again, Paul feels, most addictions are trauma based. They are adaptive behaviors. Another reason he doesn’t think alcoholism is genetic is because alcoholism is rapidly on the rise. Gene’s take thousands, millions of years to evolve. Gene’s can’t explain the ten fold increase in alcoholism we’ve seen in the last couple centuries.

That being said, we do want to share different perspectives on alcoholism. 

Dr. Huberman feels alcoholism is genetic. He does mention that there is no blood test, fingerprint test, or bio marker to indicate this addiction gene.  Dr. Huberman says the best way to “identify” alcoholics and non alcoholics is by putting drinkers in two bins. One bin is the group of people who have a couple of drinks and then get tired with a nodding head, or they feel sedated. The other bin of people is the group that has a couple of drinks and gets energized and are not sedated. The drowsy group after a couple drinks are your normal drinkers. The let’s go streaking in the quad and bring your green hat group are the future alcoholics.

Is it genetic based, or trauma based. Most likely it isn’t 100% one or the other.  It’s most likely a combination of 57,680 different things.

Again, we don’t recommend getting too caught up in all this. At the end of the day, you’ve got a drinking problem. Knowing what alcohol does to your prefrontal cortex isn’t going to keep you sober in the long run. 

Find what works for you…and go with that!

***Taken from Recovery Elevator Podcast, episode 396, host Paul Churchill***